Main Field(s) of Research, Abstract
The main focus of our research is to study the regulation of DNA damage response (DDR) processes during the cell cycle in human cells. To maintain genomic integrity - an important factor in the aetiology of cancer - it is crucial that cells respond differently to DNA damage in different phases of the cell cycle.
Within this broad area of research, we are particularly interested in the regulation of DNA double-strand break (DSB) repair by post-translational modifications (e.g protein phosphorylation).
As an example, we have recently found that CDK-mediated phosphorylation of the human CtIP protein determines if a DSB is repaired by homologous recombination or via less accurate, alternative DSB repair pathways.
We are mainly working on three projects:
1. The role of human CtIP in DSB repair
2. The regulation of DSB repair by post-translational modification(s)
3. The identification of novel factors implicated in the DDR
Main Fields of Research, Keywords
DNA double-strand breaks, DNA repair, DNA damage response, Cell cycle, Posttranslational modification
Special Techniques and Equipment
A broad spectrum of techniques in biochemistry, molecular and cellular biology is being employed in these studies, including modern proteomics and imaging technology.
Education and Training
We have training opportunities for Master students, PhD students and PostDocs