Prof. Dr. Moch Holger

Main Field(s) of Research, Abstract
The main focus of our work is the study of novel biomarkers for the better evaluation of prognosis of various cancer types as well as the study of potential predictive markers (“translational research”). We focus on novel methods for translating basic science observations into tests which may potentially be clinically applicable in the area of cancer. This work is done in collaboration with investigators in the University Hospital Zurich (Oncology, Gynecology, Urology, Thoracic Surgery), the ETH, as well as in the United States. We have developed a tissue microarray core in order to evaluate multiple biomarkers in a large number of clinical samples. We work closely with researchers to create the necessary informatics tool to deal with clinical pathology and image data associated with the tissue microarray studies. The development of tissue-based infrastructure is critical in translating observations from cDNA expression array analysis of samples from primary tumors as well as metastases. In collaboration with the oncology (Prof. A. Knuth) we are interested in the evaluation of cancer testis antigens as well as differentiation antigens.
We also collaborate with groups at the ETH (Prof. Dr. W. Krek) in the analysis of different molecular pathways (PTEN, HIF, VHL, CXCR4) in different tumors.

Main Fields of Research, Keywords
Kidney cancer, breast cancer, mesothelioma, chemokine receptors, VHL/HIF pathway, tumor-specific antigens, prognostic and predictive biomarkers.

Special Techniques and Equipment
All standard methods of molecular pathology are being used in our studies. The technology of direct sequencing, fluorescence in situ hybridization, immunohistochemistry, tissue microarray, cell culture and proteomics are extensively utilized.

Education and Training
The Institute holds regular seminars with speakers from the whole world. We also hold regular journal clubs and progress report meetings.