Prof. Dr. Hengartner Michael

Main Field(s) of Research, Abstract
Our group uses the small nematode C. elegans as a model system to study the molecular control of apoptosis (programmed cell death). Our goal is the identification and characterization of the genes that regulate the various steps of apoptosis, from the decision of individual cells to die, to the recognition and removal of doomed cells by their neighbours. Towards these aims, we use a combination of forward, reverse, and molecular genetics, as well as functional genomics and cell culture.
Much of our research centers on the study of the pathways used by cells to induce apoptosis and cell cycle arrest in response to DNA damaging agents such as ionizing radiation or alkylating agents. Because apoptosis-inducing pathways appear to be conserved through evolution, we expect that the genes that we identify and characterize in our studies will have homologs that perform similar functions in humans.

The following projects are being pursued at the moment:
& Identification and characterization of genes that function in DNA damage response pathways
& Genetic analysis of cell proliferation and apoptosis in the C. elegans germ line
& Study of the processes that control apoptotic cell corpse recognition and engulfment

Main Fields of Research, Keywords
Apoptosis, programmed cell death, DNA damage response, checkpoints, cell cycle arrest, phagocytosis, C. elegans, genetics, functional genomics

Special Techniques and Equipment
Proteomics, genome-wide RNAi, microarrays, Q-RT-PCR, SNP mapping, Worm Sorter

Education and Training
We have training opportunities for Diploma students, PhD students, and postdoctoral fellows. Our Phd students are enrolled in one of the PhD programs of the Life Science Zurich Graduate School.