Main Field(s) of Research, Abstract
We are using viral agents as probes to investigate cell functions. How do viruses utilize cellular pathways for infection and how is this orchestrated by cell signalling? How can we use such knowledge to target therapeutic viruses into diseased cells? We currently focus on adenovirus, a human DNA-virus causing respiratory and digestive disease. Using a combined pharmacological, biochemical and reverse genetics approach together with quantitative video-microscopy, we analyze viral interactions with cell receptors, endocytosis, signalling, cytoplasmic transport and viral import into the nucleus. We aim to better define the nature of both pathogenic and therapeutic viruses and hope to increase our understanding of fundamental cellular processes in health and disease.

Main Fields of Research, Keywords
Virus entry, cell biology, membrane traffic, cytoplasmic transport, nuclear import, therapeutic viruses

Special Techniques and Equipment
Video-microscopy of live cells, proteomics.

Education and Training
We offer training opportunities for Diploma students, PhD students and postdoctoral fellows.